Synthetic pathways to 3,4,5-trihydroxypiperidines from the chiral pool

Title: Synthetic pathways to 3,4,5-trihydroxypiperidines from the chiral pool
Creator: Wood, Adam; Prichard, Kate L.; Clarke, Zane; Houston, Todd A.; Fleet, George W. J.; Simone, Michela I.
Relation: European Journal of Organic Chemistry , Issue 48, p. 6812-6829
Publisher Link: http://dx.doi.org/10.1002/ejoc.201800943
Publisher: Wiley
Resource Type: journal article
Date: 2018
Description: 3,4,5‐Trihydroxypiperidines represent a family of biologically active natural products, found to modulate principally the glycosidase enzymes. This is ascribed to their structural and electronic resemblance to the pyranose monosaccharides, their natural counterparts. Expedient syntheses are crucial to access these valuable high Fsp³ index drug leads. In this review we present the literature strategies to this class of iminosugars to spur further research into drug leads targeting the glycobiological machinery of living systems.
Subject: iminosugar; 3,4,5-Trihydroxypiperidine; glycosidase; chiral pool; synthesis
Identifier: http://hdl.handle.net/1959.13/1416674
Identifier: uon:37093
Identifier: ISSN:1434-193X
Language: eng
Reviewed

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